Radioprotectant S,2-aminoethylisothiouronium bromide hydrobromide

Inactivation of Kell blood group antigens by 2-aminoethylisothiouronium bromide.

Human red cells incubated with a solution containing 6% 2-aminoethylisothiouronium bromide (AET) lose activity of antigens that are part of, or related to, the Kell blood group system. However, Kx antigen is not inactivated. Studies on a wide range of other blood-group antigens show no other evidence of changes and AET appears to react specifically with red-cell membrane structures that have Ke...

Radioprotectant screening for cryocrystallography.

Radiation damage continues to present a problem to crystallographers using cryocooled protein crystals at third-generation synchrotrons. Free-radical scavengers have been suggested as a possible means of reducing the rate of this damage. The screening of a large number of potential radioprotectants was undertaken with an online microspectrophotometer using cystine and cysteine to model protein ...

Amifostine as a radioprotectant.

Tracy K. Gosselin, RN, MSN, AOCN®, is the administrative director in the Department of Radiation Oncology at Duke University Medical Center in Durham, NC. Beatrice Mautner, RN, MSN, OCN®, is a clinical practice coordinator for Valley Radiotherapy Associates Medical Group, Inc., in Chatsworth, CA. (Mention of specific products and opinions related to those products do not indicate or imply endor...

Calcium-loaded erythrocytes have a defect in complement regulation distinct from that resulting from exposure to 2-aminoethylisothiouronium bromide.

Calcium-loaded red blood cells (RBCs) previously have been shown to have an increased sensitivity to complement-mediated hemolysis and particularly to lysis mediated by the C5b-9 membrane attack complex (MAC) of complement. Because RBCs exposed to 2-aminoethylisothiouronium bromide (AET) also have been shown to be particularly sensitive to the MAC, a direct comparison of calcium-loaded and AET-...

Polymorphic Study of (-)-galanthamine Hydrobromide